Ironman - Some Initial Obsevations On Iron And Parkinson's

More and more, metals are thought to play a role in Parkinson's disease. Recently iron has received a lot of attention in this regard. It seems that too much iron in particular too much heme or ferric iron may be especially bad. Be careful of that red meat!

This also means you should eat healthy portions of chelating foods. Broken record here but eggplant chelates iron and copper very well:

http://www.nasunin.com/health-benefits.php

I've also just learned that sweet potatoes chelate metals from your gut, especially mercury. Green tea is another good chelator. So if you eat these things on a daily basis they chelate the metals from your gut before they ever have a chance to get to your brain. But Nasunin in eggplant does cross the blood brain barrier to get the metals out of your brain.

Background

Reportedly the rate limiting factor in the production of dopamine is the cellular production of tyrosine hydroxylase.

 It says here:

https://en.m.wikipedia.org/wiki/Tyrosine_hydroxylase

 That when Fe(III) is present, tyrosine hydroxylase is deactivated. So maybe this is the whole problem, Fe(I,II) enter the brain, accumulate, get oxidized, and subsequently deactivate the enzyme.  Perhaps the cells are not dead at all, it's just the enzyme is deactivated by the iron. Then subsequently since L-DOPA is not being produced the melanin disappears. there's got to be something we can inject in there to precipitate the iron and get it out.  then full function would be restored perhaps!

Digging a little further:

http://m.jbc.org/content/271/40/24395.full

We find our friend tetrahydrobiopterin reduces ferric (Fe+++) to (Fe++) ferrous on the TH enzyme, reactivating it: "As noted above, metal replacement studies have implicated ferrous iron as the active species in tyrosine hydroxylase. This suggests that the iron must be reduced during or before the catalytic cycle. As shown here, either dithionite or 6-methyltetrahydropterin can supply the electrons for the reduction. The physiological reductant is most likely tetrahydrobiopterin, given the ready reduction of the iron by 6-methyltetrahydropterin."

So maybe tetrahydrobiopterin could be an option. Here are some other options for reducing iron in the body I found that may be of interest:

This site had an iron-reducing cookbook it offered, and had this food for thought:

"Mismanaged iron in the brain has been observed in autopsies of people with neurodegenerative diseases: Alzheimer's, early onset Parkinson's, epilepsy, multiple sclerosis, and Huntington's disease."

http://www.hemochromatosis.org/

Here are some recent observations on of all things – therapeutic bloodletting! :

Blood letting increases serum oxidation resistance:
https://www.ncbi.nlm.nih.gov/m/pubmed/7852918/

21st century bloodletting reduces cardiovascular risk

https://www.sciencedaily.com/releases/2012/05/120529211645.htm

Here's a little more thought on the topic:

Evidence conflicts on iron’s role in Parkinson’s disease

https://www.sciencenews.org/article/evidence-conflicts-irons-role-parkinsons-disease

Rock Steady Boxing & I Were Featured On The Local News Yesterday

Oakland's KTVU channel 2 ran a story last evening on Rock Steady Boxing. They were generous in the segments on my work. Here's the video of the segment:

https://m.facebook.com/story.php?story_fbid=1480703995285490&id=142081079147795

We're still looking for Northern California participants for our eggplant-juice for Parkinson's pilot.  Find out about Aubergine Juice at:

http://auberginejuice.weebly.com/about-us.html

Mannitol: Natural Sources / Eggplant Juice Booster

Mannitol: Natural Sources

With the recent studies out of Israel ( https://www.youtube.com/watch?v=0MfO3WySZ_4 ) that a naturally occurring, very low glycemic index sweetener called mannitol can reduce alpha synuclein levels in Parkinsonian subjects by as much as 70 percent, I thought I'd look further into some of the natural sources in fruits, vegetables, and other foods.  The reported therapeutic dose was in the range of 1 tablespoon per day, which is near the level at which pharmaceutical grade processed mannitol is used as a laxative.  A "win-win" for those with PD!

Here are a few things I found (some low-hanging fruit):

Seaweed - 20%, https://en.wikipedia.org/wiki/Mannitol

Strawberries, celery, onions, pumpkins and mushrooms are particularly good sources.
https://www.sugar.org/other-sweeteners/sugar-alcohols/

Celery, 15% by weight, http://link.springer.com/article/10.1007%2Fs00217-003-0663-x

Pineapple (up to 70% of total sugars is mannitol), carrots, plums, http://www.ehow.com/list_6922759_vegetables-fruits-contain-sugar-alcohol_.html
(total sugar content in pineapple, 10% per http://foodscience.wikispaces.com/Pineapple, so about 7% mannitol)

Shiitake mushrooms, 20-50% dry weight, http://www.davidmoore.org.uk/Assets/Printed_documents/my_reprints/1994_TanMoore_High_concentrations_mannitolshiitake.pdf

Sicilian Olives, 3-18% dry weight depending on cultivar, best is:
Biancolilla di Caltabellotta
http://ccsenet.org/journal/index.php/jas/article/view/31277

Conversions

Mannitol powder is about 1.52g/cm^3 in density (.793 ounces per tablespoon, or 22.48g/tbsp.), so here's a set of estimates for how many ounces (by weight) you'd have to eat or juice to get one tablespoon of mannitol:

Seaweed - 4 ounces, 112.4g
Celery - 5.3 ounces, 149.9g
Pineapple - 11.3 ounces, 321.1g
Shiitake mushrooms - 1.5 to 4 ounces
Biancolilla di Caltabellotta olives - 4.4 to 26.4 ounces

Newest Eggplant Juice Recipe:

Per day, in fractions each four hours:

1 quart eggplant juice, 2tsp turmeric, 1/2 teaspoon black pepper, 4tsp mannitol powder - shaken vigorously.

I've been trying this for two weeks. It's helped so far.  I'll try to keep you all posted.

God Bless,

Glen

If you're in Northern California, find out about our juice pilot at:
www.auberginejuice.weebly.com

Also checkout my book at:
https://www.amazon.com/dp/B00MEBATMW#_
 

Aubergine Juice Produces 2nd Shipment Of Eggplant Juice For Parkinson's

On Sunday December 4, Aubergine Juice produced its second shipment of eggplant juice for clients with Parkinson's in Northern California. Clients are reporting relief of some symptoms.

Here's the crew and I hard at work:

Can eggplant juice reduce your Parkinson’s symptoms?

Join our Northern California eggplant juice pilot program and find out.

To find out more visit:

www.auberginejuice.weebly.com

Testimonial On Eggplant From Aunt Bean

I hadn't before seen this testimonial from Aunt Bean on the anti-Parkinson's power of eggplant:

http://www.favabeans.parkinsonsrecovery.com/fava-bean-sprouts-and-eggplant

We're still accepting applicants for our eggplant juice pilot:

www.auberginejuice.weebly.com

The first shipments of juice are planned for this coming week, October 23, 2016.

God Bless

Glen

Too Much Ammonia?

Ammonia buildup from poor methylation resulting from MTHFR 1298c gene mutation?

Worth a shot.  Switching part of my laxative regimine to lactulose,  which lowers serum ammonia also.  Many articles suggest high ammonia levels correlate with PD, such as this one:

http://www.ncbi.nlm.nih.gov/m/pubmed/11240569/

May also explain part of why the eggplant juice has been working well, since it drives the urea/uric acid production, thus disposing ammonia.

Special Guest: Mr. David Spry; Recorded Podcast Of Sunday Connections, July 31

Sunday Connections, July 31, 2016
www.parkinsonsrecovery.com

A spirited discussion was had regarding the power of food and knowledge in fighting Parkinson's disease.

The prevailing message:  You can take control and play offense!

I started the hour by recapping my story and status - now more than 3-1/2 years after I radically changed my diet and lifestyle.  I also explained some new observations I've made regarding homeostasis and PD.  Briefly, I summarized the objectives and status of the company I'm founding to provide eggplant juice to Parkinson's sufferers worldwide - Aubergine Juice.

Mr. David Spry from the UK then joined the discussion and told his powerful story of how he totally changed the game with his condition.  By harnessing the knowledge from genetic and nutritional testing, David changed his diet and lifestyle and reaped the benefits!

You can listen to the podcast at:

Event Page: http://iTeleseminar.com/87187242

Find more from David Spry and other PD fighters at:

https://www.facebook.com/groups/pd.fighters.united/

Join The Juice:

There's still time and slots available to join Aubergine Juice's eggplant juice for PD pilot. Join Worldwide at:
www.auberginejuice.weebly.com